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Umulis, D. M., Shimmi, O., O'Connor, M. B., Othmer, H.G., (2010) Organism-scale modeling of early Drosophila development by Bone Morphogenetic Proteins. Dev. Cell in press
Okamoto, N., Yamanaka N., Yagi, Y.,, Nishida, Y., Kataoka, H., O’Connor, M.B., and Mizoguchi, Y. (2009) Fat body derived IGF-like peptide regulates post-feeding growth in Drosophila. Dev. Cell 17: 885–891
Rewitz K.F., Yamanaka, N., Gilbert, L.I. and O’Connor M.B. (2009) Prothoracicotropic hormone activates the receptor tyrosine kinase Torso to initiate insect metamorphosis Science 326: 1403-5
Jensen, P.A. and Zheng, X. Lee, T. and O’Connor M.B. (2009) The Drosophila Activin-like ligand Dawdle signals preferentially through a specific isoform of the Type-I receptor Baboon. Mechanism of Development 126: 950-7
Umulis, D.M., O’Connor, M.B., and Blair, S.S, (2009) Extracellular regulation of BMP signaling. Development 136: 3715-3728.
Warren J.T., O'Connor M.B., Gilbert L.I. (2009) Studies on the Black Box: incorporation of 3-oxo-7dehydrocholesterol into ecdysteroids by Drosophila melanogaster and Manduca sexta. Insect Biochem Mol Biol. 39: 677-87
Rewitz, K. F., Larsen, M R., Lobner-Olesen, A., Rybczynski, R., O’Connor, M. B., Gilbert, L.I. (2009) A Phosphoproteomics Approach to Elucidate Neuropeptide Signal Transduction Controlling Insect Metamorphosis 39: 475-483 Insect Molec Bio. and Biochem.
Merino, C., González, M., Penney, J., Moujahidine, M., O’Connor, M.B., Verheyen E.M., and Haghighi, P. (2009) Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila NMJ. Journal of Cell Science 185: 713-725
Carlson, E.S., Tkac, I., Mafid, R., O’Connor, M.B., Andrews, N.C., Schallert, T., Gunshin, H., Petryk, A., and Georgieff, M.K. (2009) Iron is Essential for Neuron Development and Memory Function in Mouse Hippocampus. J. Nutrition 139: 672-9
Zhu, C*., Bornemann, D*., Zhitomirsky, D., Miller, E., O’Connor M.B., and Simon, J.A., (2008) Drosophila Histone Decetylase-3 Controls Imaginal Disc Size Through Suppression of Apoptosis, PLOS Genetics, 4 e100009
Zhu, C., Boone, J., Jensen, P.A., Hann, S., Podemski, L., Locke, J., Doe, C.Q., and OConnor, M.B’. (2008) Drosophila dActivin and the Activin-Like product Dawdle function redundantly to regulate proliferation in the Drosophila larval brain. Development 135: 513-521
Serpe, M., Umulis, D., Ralston, A., Chen, J., Olson, D.J., Avanesov, A., Othmer, H., O’Connor , M.B., and Blair, S.S. (2008) The BMP binding protein Cv-2 is a short-range, concentration-dependant biphasic modulator of BMP signaling. Dev. Cell 14: 940-953
Rewitz K.F., O’Connor M.B., and Gilbert L.I. Evolution of the insect Halloween family of cytochrome P450s: phylogeny, gene organization and functional conservation. (2007) Insect Biochem and Mol Bio 37: 741-53
Knox, S.,*, Ge* H., Ren, Y. Dimitroff, B.D., Howe, K.A.. Arsham, A.M., Easterday, M.C., Neufeld, T.P., O’Connor M.B., Selleck., S.B. (2007) Mechanisms of TSC-mediated Control of Synapse Assembly and Axon Guidance. Plos One , 2(4): e 375
Sun, M., Thomas, M.J., Herder, R., Selleck, S.B., O'Connor, M.B., (2007) Presynaptic contributions of Chordin to hippocampal plasticity and spatial learning. J. Neuroscience 27: 740-50
McBrayer, Z.*, Ono, H.*, Shimell, MJ*, Parvy, J.-P., Beckstead, R.B., Warren, J.T., Thummel, C.S., Dauphin-Villemant, C., Gilbert, L.I., and O’Connor, M.B. (2007) Prothoracicotropic hormone regulates developmental timing and body size in Drosophila. Dev. Cell 13: 857-871
Ting, C-Y., Herman, T., Yonekura, S., Gao, S., Wang, J., Serpe, M., O’Connor, M.B., Zipursky, S.L., and Lee C-H. (2007) Tiling of R7 axons in the Drosophila Visual System is mediated both by transduction of Activin signaling to the nucleus and by mutual repulsion. Neuron, 56: 293-806
Umulis, D., O’Connor, M.B. and Othmer, H. (2007) Robustness of Embryonic spatial patterning in Drosophila melanogaster. Curr. Top. Dev. Biol. 81: 65-111
Serpe M, O'Connor MB. (2006 Dec) The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance. Development. 133(24):4969-79.
Takaesu NT, Hyman-Walsh C, Ye Y, Wisotzkey RG, Stinchfield MJ, O'connor MB, Wotton D, Newfeld SJ. ( 2006)
dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2.
Genetics 174(3):1299-313. Epub
Ono H, Rewitz KF, Shinoda T, Itoyama K, Petryk A, Rybczynski R, Jarcho M, Warren JT, Marques G, Shimell MJ, Gilbert LI, O'Connor MB. 2006 Oct Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera. Dev Biol 15;298(2):555-70. Epub
Umulis DM, Serpe M, O'Connor MB, Othmer HG. Robust, bistable patterning of the dorsal surface of the Drosophila embryo. Proc Natl Acad Sci U S A 103(31):11613-8. Epub.
Jadrich JL, O'Connor MB, Coucouvanis E (2006). The TGF{beta} activated kinase TAK1 regulates vascular development in vivo. Development 133, 1529-41.
Warren JT, Yerushalmi Y, Shimell MJ, O'Connor MB, Restifo LL, Gilbert LI (2006). Discrete pulses of molting hormone, 20-hydroxyecdysone, during late larval development of Drosophila melanogaster: correlations with changes in gene activity. Dev. Dyn. 235, 315-26.
O'Connor MB, Umulis D, Othmer HG, Blair SS (2005). Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing. Development 133, 183-93.
Takaesu NT, Herbig E, Zhitomersky D, O'Connor MB, Newfeld SJ (2005). DNA-binding domain mutations in SMAD genes yield dominant-negative proteins or a neomorphic protein that can activate WG target genes in Drosophila. Development 132, 4883-94.
Parvy JP, Blais C, Bernard F, Warren JT, Petryk A, Gilbert LI, O'Connor MB, Dauphin-Villemant C (2005). A role for betaFTZ-F1 in regulating ecdysteroid titers during post-embryonic development in Drosophila melanogaster. Dev. Biol. 282, 84-94.
Shimmi O, Ralston A, Blair SS, O'Connor MB (2005). The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. Dev. Biol. 282, 70-83.
Serpe M, Ralston A, Blair SS, O'Connor MB (2005). Matching catalytic activity to developmental function: tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing. Development 132, 2645-56.
Adachi-Yamada T, Harumoto T, Sakurai K, Ueda R, Saigo K, O'Connor MB, Nakato H (2005). Wing-to-Leg homeosis by spineless causes apoptosis regulated by Fish-lips, a novel leucine-rich repeat transmembrane protein. Mol. Cell. Biol. 25, 3140-50.
Shimmi O, Umulis D, Othmer H, O'Connor MB (2005). Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. Cell 120, 873-86.
Petryk A, Shimmi O, Jia X, Carlson AE, Tervonen L, Jarcho MP, O'Connor MB, Gopalakrishnan R (2005). Twisted gastrulation and chordin inhibit differentiation and mineralization in MC3T3-E1 osteoblast-like cells. Bone 36, 617-26.
Jorgenson LA, Sun M, O'Connor M, Georgieff MK (2005). Fetal iron deficiency disrupts the maturation of synaptic function and efficacy in area CA1 of the developing rat hippocampus. Hippocampus 15, 1094-102.
Warren JT, Petryk A, Marques G, Parvy JP, Shinoda T, Itoyama K, Kobayashi J, Jarcho M, Li Y, O'Connor MB, Dauphin-Villemant C, Gilbert LI (2004). Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis. Insect Biochem. Mol. Biol. 34, 991-1010.
Adachi-Yamada T, O'Connor MB (2004). Mechanisms for removal of developmentally abnormal cells: cell competition and morphogenetic apoptosis. J. Biochem. 136, 13-7.
McCabe BD, Hom S, Aberle H, Fetter RD, Marques G, Haerry TE, Wan H, O'Connor MB, Goodman CS, Haghighi AP (2004). Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41, 891-905.
Johnson KG, Ghose A, Epstein E, Lincecum J, O'Connor MB, Van Vactor D (2004). Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance. Curr. Biol. 14, 499-504.
Petryk A, Anderson RM, Jarcho MP, Leaf I, Carlson CS, Klingensmith J, Shawlot W, O'Connor MB (2004). The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev. Biol. 267, 374-86.
Petryk A, Warren JT, Marques G, Jarcho MP, Gilbert LI, Kahler J, Parvy JP, Li Y, Dauphin-Villemant C, O'Connor MB (2003). Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone. Proc. Natl. Acad. Sci. U.S.A. 100, 13773-8.
Marques G, Haerry TE, Crotty ML, Xue M, Zhang B, O'Connor MB (2003). Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila. Development 130, 5457-70.
Shimmi O, O'Connor MB (2003). Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo. Development 130, 4673-82.
McCabe BD, Marques G, Haghighi AP, Fetter RD, Crotty ML, Haerry TE, Goodman CS, O'Connor MB (2003). The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron 39, 241-54.
Jadrich JL, O'Connor MB, Coucouvanis E (2003). Expression of TAK1, a mediator of TGF-beta and BMP signaling, during mouse embryonic development. Gene Expr. Patterns 3, 131-4.
Zheng X, Wang J, Haerry TE, Wu AY, Martin J, O'Connor MB, Lee CH, Lee T (2003). TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain. Cell 112, 303-15.
Adachi-Yamada T, O'Connor MB (2002). Morphogenetic apoptosis: a mechanism for correcting discontinuities in morphogen gradients. Dev. Biol. 251, 74-90.
Muller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B, Miller EL, O'Connor MB, Kingston RE, Simon JA (2002). Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111, 197-208.
Warren JT, Petryk A, Marques G, Jarcho M, Parvy JP, Dauphin-Villemant C, O'Connor MB, Gilbert LI (2002). Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 99, 11043-8.
Haerry TE, O'Connor MB (2002). Isolation of Drosophila activin and follistatin cDNAs using novel MACH amplification protocols. Gene 291, 85-93.
Marques G, Bao H, Haerry TE, Shimell MJ, Duchek P, Zhang B, O'Connor MB (2002). The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function. Neuron 33, 529-43.
Ross JJ, Shimmi O, Vilmos P, Petryk A, Kim H, Gaudenz K, Hermanson S, Ekker SC, O'Connor MB, Marsh JL (2001). Twisted gastrulation is a conserved extracellular BMP antagonist. Nature 410, 479-83.
Chavez VM, Marques G, Delbecque JP, Kobayashi K, Hollingsworth M, Burr J, Natzle JE, O'Connor MB (2000). The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. Development 127, 4115-26.
Blitz IL, Shimmi O, Wunnenberg-Stapleton K, O'Connor MB, Cho KW (2000). Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation. Dev. Biol. 223, 120-38.
Yu K, Srinivasan S, Shimmi O, Biehs B, Rashka KE, Kimelman D, O'Connor MB, Bier E (2000). Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development 127, 2143-54.
Takatsu Y, Nakamura M, Stapleton M, Danos MC, Matsumoto K, O'Connor MB, Shibuya H, Ueno N (2000). TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol. Cell. Biol. 20, 3015-26.
Shimell MJ, Peterson AJ, Burr J, Simon JA, O'Connor MB (2000). Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. Dev. Biol. 218, 38-52.
Brummel T, Abdollah S, Haerry TE, Shimell MJ, Merriam J, Raftery L, Wrana JL, O'Connor MB (1999). The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 13, 98-111.
Haerry TE, Khalsa O, O'Connor MB, Wharton KA (1998). Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila. Development 125, 3977-87.
Marques G, Musacchio M, Shimell MJ, Wunnenberg-Stapleton K, Cho KW, O'Connor MB (1997). Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins. Cell 91, 417-26.
Haerry TE, Heslip TR, Marsh JL, O'Connor MB (1997). Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila. Development 124, 3055-64.
Theisen H, Haerry TE, O'Connor MB, Marsh JL (1997). Developmental territories created by mutual antagonism between Wingless and Decapentaplegic. Development 122, 3939-48.
Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL (1996). The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell 86, 607-17.
Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL (1996). MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85, 489-500.
Chang YL, King BO, O'Connor MB, Mazo A, Huang DH (1995). Functional reconstruction of trans regulation of the Ultrabithoraz promoter by the productsof two antagonistic genes, trithorax, and Polycomb Mol Cell Biol 15, 6601-12.
Letsou A, Arora K, Wrana JL, Simin K, Twombly V, Jamal J, Staehling-Hampton K, Hoffmann FM, Gelbart WM, Massague J, O'Connor MB, et al (1995). Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Cell 80, 899-908.
47) Arora K, Dai H, Kazuko SG, Jamal J, O'Connor MB, Letsou A, Warrior R (1995). The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family. Cell 81, 781-90.
Chiang A, O'Connor MB, Paro R, Simon J, Bender W (1995). Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex. Development 121, 1681-9.
Nguyen T, Jamal J, Shimell MJ, Arora K, O'Connor MB (1995). Characterization of tolloid-related-1: a BMP-1-like product that is required during larval and pupal stages of Drosophila development. Dev. Biol. 166, 569-86.
McCall K, O'Connor MB, Bender W (1995). Enhancer traps in the Drosophila bithorax complex mark parasegmental domains. Genetics 138, 387-99.
Arora K, Levine MS, O'Connor MB (1994). The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo. Genes Dev. 8, 2588-601.
Brummel TJ, Twombly V, Marques G, Wrana JL, Newfeld SJ, Attisano L, Massague J, O'Connor MB, Gelbart WM (1994). Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell 78, 251-61.
Shimell MJ, Simon J, Bender W, O'Connor MB (1994). Enhancer point mutation results in a homeotic transformation in Drosophila. Science 264, 968-71.
Childs SR, O'Connor MB (1994). Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic. Dev. Biol. 162, 209-20.
Wrana JL, Tran H, Attisano L, Arora K, Childs SR, Massague J, O'Connor MB (1994). Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex. Mol. Cell. Biol. 14, 944-50.
Kirov N, Childs S, O'Connor MB, Rushlow C (1994). The Drosophila dorsal morphogen represses the tolloid gene by interacting with a silencer element. Mol Cell Biol 14, 713-22.
Childs SR, Wrana JL, Arora K, Attisano L, O'Connor MB, Massague J (1993). Identification of a Drosophila activin receptor. Proc. Natl. Acad. Sci. U.S.A. 90, 9475-9.
Simon J, Chiang A, Bender W, Shimell MJ, O'Connor M (1993). Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products. Dev Biol 158, 131-144.
Shimell MJ, Ferguson EL, Childs SR, O'Connor MB (1991). The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1. Cell 67, 469-81.
Simon J, Peifer M, Bender W, O'Connor MB (1990). Regulatory elements of the bithorax complex that control expression along the anterior-posterior axis. EMBO J 9, 3945-3956.
O'Connor MB, Peifer M, Bender W (1989). Construction of large DNA segments in Escherichia coli. Science 244, 1307-12.
O'Connor MB, Binari R, Perkins LA, Bender W (1988). Alternative RNA products from the Ultrabithorax domain of the bithorax complex. EMBO J. 7, 435-45.
O'Connor MB, Kilbane JJ, Malamy MH (1987). Site-specific and illegitimate recombination in the oriV1 region of the F factor. DNA sequences involved in recombination and resolution. J. Mol. Biol. 189, 85-102.
Malamy MH, Rahaim PT, Hoffman CS, Baghdoyan D, O'Connor MB, Miller JF (1985). A frameshift mutation at the junction of an IS1 insertion within lacZ restores beta-galactosidase activity via formation of an active lacZ-IS1 fusion protein. J. Mol. Biol. 181, 551-5.
O'Connor MB, Malamy MH (1985). Mapping of DNA gyrase cleavage sites in vivo oxolinic acid induced cleavages in plasmid pBR322. J. Mol. Biol. 181, 545-50.
O'Connor MB, Malamy MH (1984). Site-specific recombination in the oriV1 region of the F factor. Cold Spring Harbor Symp Quant Biol 49, 421-34.
O'Connor MB, Malamy MH (1984). Role of the F factor oriV1 region in recA-independent illegitimate recombination. Stable replicon fusions of the F derivative pOX38 and pBR322-related plasmids. J. Mol. Biol. 175, 263-84.
O'Connor MB, Malamy MH (1983). A new insertion sequence, IS121, is found on the Mu dI1 (Ap lac) bacteriophage and the Escherichia coli K-12 chromosome. J. Bacteriol. 156, 669-79.
Haldenwang WG, Banner CD, Ollington JF, Losick R, Hoch JA, O'Connor MB, Sonenshein AL (1980). Mapping a cloned gene under sporulation control by inserttion of a drug resistance marker into the Bacillus subtilis chromosome. J. Bacteriol. 142, 90-8.
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